Ward G H, Yalkowsky S H
Department of Pharmaceutical Science, College of Pharmacy University of Arizona, Tucson.
J Parenter Sci Technol. 1993 Jan-Feb;47(1):40-3.
Using a rabbit ear model and techniques developed previously (1) the relationship between injection rate and injection phlebitis is investigated for amiodarone HCl and its vehicle. A number of injection rates ranging from 0.02 to 3.0 ml/min are studied using this model. Thermal measurements and visual evaluations are used for phlebitis quantitation. The severity of phlebitis is found to be dependent upon the injection rate for amiodarone HCl while the vehicle did not produce phlebitis at any rate. Strong correlations between the thermal measurements and visual evaluations are found for both amiodarone HCl and its vehicle.
利用兔耳模型和先前开发的技术(1)，研究了盐酸胺碘酮及其溶媒的注射速率与注射性静脉炎之间的关系。使用该模型研究了0.02至3.0毫升/分钟范围内的多种注射速率。热测量和视觉评估用于静脉炎定量。发现盐酸胺碘酮的静脉炎严重程度取决于注射速率，而溶媒在任何速率下均未产生静脉炎。盐酸胺碘酮及其溶媒的热测量和视觉评估之间均发现有很强的相关性。
