Sun A, Lin S C, Chu C T, Chiang C P
School of Dentistry, College of Medicine, National Taiwan University, Taipei, ROC.
J Oral Pathol Med. 1993 Feb;22(2):60-3. doi: 10.1111/j.1600-0714.1993.tb00044.x.
The frequencies of HLA-DR and DQ antigens in 24 Chinese patients with Behçet's disease (BD) were calculated and compared with those in 130 healthy control Chinese and those in 80 Chinese patients with recurrent oral ulcers (ROU). Although an increased trend of DRw6 and DRw8 antigens in patients with BD was noted, there was no significant difference in frequencies of HLA-DR and DQ antigens between patients with BD and healthy control subjects or patients with ROU after correction of P values (Pc > 0.05). Further analysis of our data of the phenotype frequencies of DRw6 and DRw8 antigens according to the subtypes of BD also showed the increased frequencies of DRw6 and DRw8 antigens in patients with mucocutaneous type of BD as compared with those in healthy control subjects. However, only the phenotype frequency of DRw8 antigen in patients with mucocutaneous type of BD was significantly higher than that in patients with ROU (P < 0.005, Pc < 0.05, relative risk = 17.7, and etiologic fraction = 0.30). This significant increase of the phenotype frequency suggests that the gene coding for HLA-DRw8 antigen in patients with ROU was only partially (30%) responsible for susceptibility to the mucocutaneous type of BD.
计算了24例中国白塞病（BD）患者的HLA-DR和DQ抗原频率，并与130例健康中国对照者以及80例复发性口腔溃疡（ROU）中国患者的频率进行了比较。尽管注意到BD患者中DRw6和DRw8抗原频率有增加趋势，但校正P值后（Pc>0.05），BD患者与健康对照者或ROU患者之间HLA-DR和DQ抗原频率无显著差异。根据BD亚型对我们的DRw6和DRw8抗原表型频率数据进行的进一步分析还显示，与健康对照者相比，黏膜皮肤型BD患者中DRw6和DRw8抗原频率增加。然而，仅黏膜皮肤型BD患者中DRw8抗原的表型频率显著高于ROU患者（P<0.005，Pc<0.05，相对风险=17.7，病因分值=0.30）。这种表型频率的显著增加表明，ROU患者中编码HLA-DRw8抗原的基因仅部分（30%）导致黏膜皮肤型BD的易感性。
