缓解与苯二氮䓬类药物戒断相关的睡眠相关停药症状：一种新方法。

Alleviating sleep-related discontinuance symptoms associated with benzodiazepine withdrawal: a new approach.

作者信息

Shapiro C M, MacFarlane J G, MacLean A W

机构信息

Sleep Disorders Clinic, University of Toronto, Canada.

出版信息

J Psychosom Res. 1993;37 Suppl 1:55-7. doi: 10.1016/0022-3999(93)90027-d.

DOI:10.1016/0022-3999(93)90027-d

PMID:8445587

Abstract

There is limited information on the time course of recovery of sleep architecture in patients withdrawn from benzodiazepines (BDZ). This study examined the effects of substituting a new class of hypnotic drugs, namely the cyclopyrrolones, for current BDZs in patients presenting with BDZ dependence. The results indicated a clear improvement in a variety of sleep parameters after commencing with a cyclopyrrolone (zopiclone). These changes remained to some extent after zopiclone was discontinued. Also, the absence of certain withdrawal effects (i.e. rebound insomnia) upon discontinuation of zopiclone allows for patients to be carried through a potentially difficult period after stopping BDZs, while expediting the eventual discontinuation of all hypnotic medication.

摘要

关于停用苯二氮䓬类药物（BDZ）的患者睡眠结构恢复的时间进程，相关信息有限。本研究调查了用一类新型催眠药物（即环吡咯酮类）替代目前使用的BDZ对BDZ依赖患者的影响。结果表明，开始使用环吡咯酮类药物（佐匹克隆）后，各种睡眠参数有明显改善。停用佐匹克隆后，这些变化仍在一定程度上存在。此外，停用佐匹克隆后没有出现某些戒断效应（即反弹性失眠），这使得患者在停用BDZ后能够度过一个可能困难的时期，同时加快最终停用所有催眠药物的进程。