Vasantha N, Venkatachari S A, Mohan P M, Babu K S
Experientia. 1977 Feb 15;33(2):238-9. doi: 10.1007/BF02124087.
It is shown that Km of ChE is not affected by the neurohormones but Vmax is increased and decreased in presence of acceleratory and inhibitory neurohormones respectively. Hence it is suggested that the neurohormones might modulate the enzyme activity be altering the maximal velocities (Vmax) rather than affecting the enzyme affinity (Km) towards the substrate.
结果表明，胆碱酯酶（ChE）的米氏常数（Km）不受神经激素影响，但在存在促进性和抑制性神经激素时，最大反应速度（Vmax）分别升高和降低。因此，有人提出神经激素可能通过改变最大反应速度（Vmax）而非影响酶对底物的亲和力（Km）来调节酶活性。
