泼尼松龙的酸性代谢物。
Acidic metabolite of prednisolone.
作者信息
Lee H J
出版信息
Experientia. 1977 Feb 15;33(2):253-4. doi: 10.1007/BF02124095.
PMID:844579
Abstract
The metabolic fate of the 17beta-ketol side chain of (21-3H) prednisolone was studied with an enzyme preparation from male golden hamster liver. The acidic metabolite of prednisolone was identified by mass spectrometry as 11beta, 17alpha,20epsilon-trihydroxy-3-oxo-1,4-pregnadien-21-oic acid. The enzyme showed substrate specificity, depending on the nature of substituent on the steroid nucleus.
摘要
用雄性金黄仓鼠肝脏的酶制剂研究了（21-³H）泼尼松龙17β-酮醇侧链的代谢命运。通过质谱法将泼尼松龙的酸性代谢物鉴定为11β，17α，20ε-三羟基-3-氧代-1,4-孕二烯-21-酸。该酶表现出底物特异性，这取决于甾体核上取代基的性质。
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