White S S, Zarins C K, Giddens D P, Bassiouny H, Loth F, Jones S A, Glagov S
Georgia Institute of Technology, Atlanta 30332.
J Biomech Eng. 1993 Feb;115(1):104-11. doi: 10.1115/1.2895456.
Flow behavior in models of end-to-side vascular graft anastomoses was studied under steady and pulsatile flow conditions. Models were constructed to simulate geometries employed in experimental studies on intimal thickening in a canine model. Reynolds numbers, division of flow in the outflow tracts and the pulsatile waveform employed were taken from measurements obtained in the canine model. Flows in the scaled-up, transparent models were visualized with white, neutrally buoyant particles which were photographed under laser illumination and also recorded on video tape under bright incandescent light. Strong, three-dimensional helical patterns which formed in the anastomotic junction were prominent features of the flow fields. Regions of low wall shear, oscillatory wall shear and long particle residence time were identified from the flow visualization experiments. Comparisons with the limited qualitative data available on intimal thickening in vascular graft anastomoses suggest a relation between localization of vascular intimal thickening and those surfaces experiencing low shear and long particle residence time.
在稳定流和脉动流条件下，研究了端侧血管移植吻合模型中的流动行为。构建模型以模拟犬模型中内膜增厚实验研究中使用的几何形状。雷诺数、流出道中的血流分配以及所采用的脉动波形均取自犬模型中的测量值。在放大的透明模型中的流动通过白色、中性浮力颗粒进行可视化，这些颗粒在激光照明下拍照，并在明亮的白炽灯下录制在录像带上。吻合口处形成的强烈三维螺旋模式是流场的显著特征。通过流动可视化实验确定了低壁面切应力区域、振荡壁面切应力区域和长颗粒停留时间区域。与血管移植吻合术中内膜增厚的有限定性数据的比较表明，血管内膜增厚的定位与那些经历低切应力和长颗粒停留时间的表面之间存在关联。
