小牛胸腺组蛋白及其F2和F3组分对植物血凝素刺激人淋巴细胞的影响。
Effect of calf thymus histone and its fractions F2 and F3 on human lymphocyte stimulation by phytohaemagglutin.
作者信息
Cinátl J, Korcáková L, Svobodová J, Lostický C, Hasková V
出版信息
Folia Biol (Praha). 1977 Jan;23(1):35-9.
The effect of exogenous calf thymus histone and its fractions F2 and F3 on blastic transformation of human lymphocytes stimulated by phytohaemagglutinin was investigated. It was found that histones can not only inhibit, but also potentiate phytohaemagglutinin-induced blastic transformation of lymphocytes. This effect depends on the amount of histones in the medium and most probably also on individual sensitivity of lymphocytes. The arginine-rich histone fraction (F3) displayed the greatest inhibitory effect on lymphocyte stimulation.
研究了外源性小牛胸腺组蛋白及其F2和F3组分对植物血凝素刺激的人淋巴细胞的 blast 转化的影响。发现组蛋白不仅可以抑制，还可以增强植物血凝素诱导的淋巴细胞 blast 转化。这种效应取决于培养基中组蛋白的量，很可能还取决于淋巴细胞的个体敏感性。富含精氨酸的组蛋白组分（F3）对淋巴细胞刺激表现出最大的抑制作用。
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