Silberberg R
Exp Cell Biol. 1977;45(1-2):1-8. doi: 10.1159/000162853.
Blotchy mice which carry a gene causing inadequate cross-linking of collagen were investigated for the progress of epiphyseal growth and for the appearance of changes in the knee joints following cessation of growth. In male mice of the strain, which are hemizygous for the gene, early growth proceeded in a histologically normal fashion, although the metaphyseal bone was less abundant than usual. From the age of 3 1/2 months on, the animals developed osteoarthrosis of the knee joints and at the time of death at 5-6 1/2 months of age, 88% of the animals had osteoarthrosis. The findings are discussed with special reference to a possible role of the collagen of the articular cartilage in the pathogenesis of some forms of osteoarthrosis.
对携带导致胶原蛋白交联不足基因的斑点小鼠进行了研究，观察其骨骺生长进程以及生长停止后膝关节变化的出现情况。在该基因半合子的雄性小鼠品系中，早期生长在组织学上以正常方式进行，尽管干骺端骨量比正常情况少。从3个半月龄开始，这些动物出现膝关节骨关节炎，在5至6个半月龄死亡时，88%的动物患有骨关节炎。特别参照关节软骨胶原蛋白在某些形式骨关节炎发病机制中的可能作用对这些发现进行了讨论。
