Rao G N, Haseman J K
National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Nutr Cancer. 1993;19(1):21-30. doi: 10.1080/01635589309514233.
Amount and type of fat and energy density of diets may influence tumor incidences. The purpose of this report is to summarize the influence of corn oil gavage and different nonpurified diets on spontaneous tumor incidences in 64 diet and 59 corn oil gavage control groups in two-year studies involving approximately 6,100 control Fischer 344 rats of each sex. The maximum mean body weight attained during the course of the study, survival at 106 weeks of age, and spontaneous tumor incidences of groups fed different nonpurified diets with or without corn oil gavage were summarized and evaluated for differences. Male rats fed NIH-07 open-formula diet with or without corn oil gavage had significantly higher body weight, lower survival, and higher incidence of pancreatic acinar cell tumors than rats fed commercial proprietary diets with or without corn oil gavage. Female rats fed NIH-07 diet with or without corn oil gavage had significantly higher body weights and pancreatic tumor incidences than groups fed commercial diets. Time-related trends could account for other apparent differences in tumor incidences between the groups fed commercial and NIH-07 diets. Corn oil gavage significantly increased the body weight and pancreatic tumor incidences but decreased the incidence of leukemia, a lethal tumor, which resulted in higher survival in male rats. Corn oil gavage significantly lowered the body weight and anterior pituitary tumor incidence in female rats. The pancreatic acinar cell tumor incidence appears to be due to a combination of fat intake and body weight.
饮食中脂肪的含量和类型以及能量密度可能会影响肿瘤发生率。本报告的目的是总结在两项为期两年的研究中，玉米油灌胃和不同非纯化饮食对64个饮食组和59个玉米油灌胃对照组自发肿瘤发生率的影响，这些研究涉及约6100只各性别的对照Fischer 344大鼠。总结并评估了在研究过程中达到的最大平均体重、106周龄时的存活率，以及喂食不同非纯化饮食（有或没有玉米油灌胃）的各组的自发肿瘤发生率之间的差异。喂食含或不含玉米油灌胃的NIH-07开放式配方饮食的雄性大鼠，比喂食含或不含玉米油灌胃的商业专用饮食的大鼠体重显著更高、存活率更低，胰腺腺泡细胞瘤的发生率更高。喂食含或不含玉米油灌胃的NIH-07饮食的雌性大鼠，比喂食商业饮食的组体重显著更高，胰腺肿瘤发生率也更高。与时间相关的趋势可能解释了喂食商业饮食和NIH-07饮食的组之间在肿瘤发生率上的其他明显差异。玉米油灌胃显著增加了体重和胰腺肿瘤发生率，但降低了白血病（一种致命肿瘤）的发生率，这导致雄性大鼠存活率更高。玉米油灌胃显著降低了雌性大鼠的体重和垂体前叶肿瘤发生率。胰腺腺泡细胞瘤的发生率似乎是脂肪摄入和体重共同作用的结果。
