大鼠体内一个与主要组织相容性复合体相关的基因座对二乙基亚硝胺致癌作用的抗性有至关重要的影响。
A major histocompatibility complex-linked locus in the rat critically influences resistance to diethylnitrosamine carcinogenesis.
作者信息
Melhem M F, Kunz H W, Gill T J
机构信息
Department of Pathology, University of Pittsburgh School of Medicine, PA 15261.
出版信息
Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1967-71. doi: 10.1073/pnas.90.5.1967.
Abstract
Major histocompatibility complex (MHC)-linked deletions in the rat are associated with defects in growth and development and increased susceptibility to chemical carcinogens. The present study maps a locus critical for determining susceptibility to diethylnitrosamine (DEN) carcinogenesis by using two groups of MHC-recombinant rats congenic for the MHC and its linked region. Resistance to DEN segregates with a locus (rcc+) that maps between RT1.E and ft, and its homozygous loss markedly increases susceptibility to DEN. Non-MHC genes do not significantly influence the susceptibility of these strains to DEN. The existence of the rcc locus adds support to our hypothesis that some genes in the MHC-linked region play a major role in both normal and abnormal growth.
摘要
大鼠体内主要组织相容性复合体（MHC）相关的缺失与生长发育缺陷以及对化学致癌物易感性增加有关。本研究通过使用两组在MHC及其连锁区域同基因的MHC重组大鼠，定位了一个对决定二乙基亚硝胺（DEN）致癌易感性至关重要的基因座。对DEN的抗性与一个位于RT1.E和ft之间的基因座（rcc+）共分离，该基因座的纯合缺失显著增加了对DEN的易感性。非MHC基因对这些品系对DEN的易感性没有显著影响。rcc基因座的存在支持了我们的假设，即MHC连锁区域中的一些基因在正常和异常生长中都起主要作用。
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