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携带生长与繁殖复合体的大鼠的卵巢缺陷

Ovarian defect in rats carrying the growth and reproduction complex.

作者信息

Geyer S J, Gill T J, Kunz H W

出版信息

J Immunogenet. 1983 Feb;10(1):55-9. doi: 10.1111/j.1744-313x.1983.tb01017.x.

DOI:10.1111/j.1744-313x.1983.tb01017.x
PMID:6841983
Abstract

The growth and reproduction complex contains recessive genes (grc) which influence body weight and gonadal development. Homozygous males are sterile, and they have an arrest of spermatogenesis at the primary spermatocyte stage. Homozygous females are fertile but have a reduced reproductive capacity. The data presented in this paper show that the latter defect is associated with a decrease in the relative number of secondary ovarian follicles and an increase in the number of atretic follicles. This finding indicates that most of the primary follicles do not mature properly. Thus, the genetic defect in gametogenesis controlled by the grc appears to occur at the same stage of development in both females and males.

摘要

生长与繁殖复合体包含影响体重和性腺发育的隐性基因(grc)。纯合雄性不育,其精子发生在初级精母细胞阶段停滞。纯合雌性可育但生殖能力下降。本文所呈现的数据表明,后一种缺陷与次级卵巢卵泡相对数量的减少以及闭锁卵泡数量的增加有关。这一发现表明大多数初级卵泡不能正常成熟。因此,由grc控制的配子发生中的遗传缺陷似乎在雌性和雄性的同一发育阶段出现。

相似文献

1
Ovarian defect in rats carrying the growth and reproduction complex.携带生长与繁殖复合体的大鼠的卵巢缺陷
J Immunogenet. 1983 Feb;10(1):55-9. doi: 10.1111/j.1744-313x.1983.tb01017.x.
2
Ultrastructural investigation of the testicular defect in rats carrying MHC-linked genes affecting development (grc).对携带影响发育的MHC连锁基因(grc)的大鼠睾丸缺陷的超微结构研究。
Am J Pathol. 1986 May;123(2):318-33.
3
Growth and reproduction complex in the rat. Genes linked to the major histocompatibility complex that affect development.大鼠的生长与繁殖复合体。与主要组织相容性复合体相关且影响发育的基因。
J Exp Med. 1980 Dec 1;152(6):1506-18. doi: 10.1084/jem.152.6.1506.
4
Rats homozygous for the grc complex have defective transport of androgen-binding protein to the epididymis, but normal secretion into the blood.grc复合体纯合的大鼠将雄激素结合蛋白转运至附睾的过程存在缺陷,但向血液中的分泌正常。
Biol Reprod. 1985 Dec;33(5):1057-63. doi: 10.1095/biolreprod33.5.1057.
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Deficiency in the regulation of testicular galactolipid sulphotransferase in rats carrying the growth-and-reproduction-complex (grc) gene.携带生长与繁殖复合体(grc)基因的大鼠睾丸半乳糖脂磺基转移酶调节缺陷。
Biochem J. 1985 Oct 15;231(2):401-5. doi: 10.1042/bj2310401.
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Gene complex controlling growth and fertility linked to the major histocompatibility complex in the rat.控制生长和生育能力的基因复合体与大鼠主要组织相容性复合体相关。
Am J Pathol. 1979 Jul;96(1):185-206.
7
A cytogenetical analysis of sterile mutants in Caenorhabditis elegans.
Can J Genet Cytol. 1980;22(3):391-403. doi: 10.1139/g80-048.
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Pcsk6 mutant mice exhibit progressive loss of ovarian function, altered gene expression, and formation of ovarian pathology.PCSK6 突变小鼠表现出进行性卵巢功能丧失、基因表达改变和卵巢病理形成。
Reproduction. 2011 Mar;141(3):343-55. doi: 10.1530/REP-10-0451. Epub 2010 Dec 23.
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Genetic and morphometric studies of the heterogeneity in the testicular defect of the Hre rat and the interaction between the Hre and grc genes.对Hre大鼠睾丸缺陷异质性以及Hre与grc基因之间相互作用的遗传学和形态学研究。
Biol Reprod. 1984 Oct;31(3):595-603. doi: 10.1095/biolreprod31.3.595.
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Mechanisms of action of major-histocompatibility-complex-linked genes affecting reproduction.影响生殖的主要组织相容性复合体连锁基因的作用机制。
Am J Reprod Immunol. 1999 Jan;41(1):23-33. doi: 10.1111/j.1600-0897.1999.tb00072.x.

引用本文的文献

1
A major histocompatibility complex-linked locus in the rat critically influences resistance to diethylnitrosamine carcinogenesis.大鼠体内一个与主要组织相容性复合体相关的基因座对二乙基亚硝胺致癌作用的抗性有至关重要的影响。
Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1967-71. doi: 10.1073/pnas.90.5.1967.