Kesner R P, Dakis M
Department of Psychology, University of Utah, Salt Lake City 84112.
Pharmacol Biochem Behav. 1993 Feb;44(2):419-24. doi: 10.1016/0091-3057(93)90484-b.
Rats with 1 or 2 mg/kg phencyclidine (PCP), 4 mg/kg PCP, or saline injections were tested for acquisition or retention performance of a spatial continuous recognition memory task. Results indicate that relative to controls and rats with injections of 1 and 2 mg/kg PCP rats with 4-mg/kg PCP injections were profoundly impaired in acquisition and somewhat impaired in retention of the task across all lags as measured by increases in latency for repeated items. Phencyclidine, through it presumed blocking action of the NMDA receptor, alters the consolidation of new spatial location information but does not have a major affect on short-term maintenance of previously learned information.
给大鼠注射1毫克/千克或2毫克/千克的苯环己哌啶（PCP）、4毫克/千克的PCP或生理盐水，然后测试它们在空间连续识别记忆任务中的习得或保持表现。结果表明，与对照组以及注射1毫克/千克和2毫克/千克PCP的大鼠相比，注射4毫克/千克PCP的大鼠在任务习得方面受到严重损害，并且在所有延迟条件下，通过重复项目潜伏期的增加来衡量，其任务保持也受到一定程度的损害。苯环己哌啶通过其假定的对N-甲基-D-天冬氨酸（NMDA）受体的阻断作用，改变了新空间位置信息的巩固，但对先前学习信息的短期维持没有重大影响。
