Kesner R P, Dakis M, Bolland B L
Department of Psychology, University of Utah, Salt Lake City 84112.
Psychopharmacology (Berl). 1993;111(1):85-90. doi: 10.1007/BF02257411.
In the first experiment rats with 1, 2, 3 or 4 mg/kg phencyclidine (PCP), or saline injections were tested for acquisition or retention of a cheese board spatial task (dry land version of a water maze). Results indicate that relative to controls or rats with injections of 1 and 2 mg/kg PCP, rats with 3 or 4 mg/kg PCP injections were impaired in acquisition and retention of the task as measured by increased distances traveled to find the correct food location. This impairment was primarily observed in between days but not within days performance. In the second experiment rats with 4 mg/kg PCP or saline injections were tested for memory performance of a delayed spatial matching-to-sample task. Results indicate that relative to controls rats with 4 mg/kg PCP injections were not impaired at either 1-5 or 30 s delays. It is suggested that PCP through its blocking action of the NMDA receptor mediates long- but not short-term memory for spatial location information as well as the ability to retrieve previously learned spatial location information.
在首个实验中，对注射1、2、3或4毫克/千克苯环利定（PCP）或生理盐水的大鼠进行了奶酪板空间任务（水迷宫的陆地版本）的获取或保持测试。结果表明，与对照组或注射1毫克/千克和2毫克/千克PCP的大鼠相比，注射3毫克/千克或4毫克/千克PCP的大鼠在任务获取和保持方面存在缺陷，这通过寻找正确食物位置时行进距离增加来衡量。这种缺陷主要在不同天数之间观察到，而非同一天内的表现。在第二个实验中，对注射4毫克/千克PCP或生理盐水的大鼠进行了延迟空间样本匹配任务的记忆表现测试。结果表明，与对照组相比，注射4毫克/千克PCP的大鼠在1 - 5秒或30秒延迟时均未受损。研究表明，PCP通过其对NMDA受体的阻断作用，介导了空间位置信息的长期而非短期记忆，以及检索先前学习的空间位置信息的能力。
