年轻卒中患者的狼疮抗凝物与纤溶系统
Lupus anticoagulant and the fibrinolytic system in young patients with stroke.
作者信息
Ferro D, Quintarelli C, Rasura M, Antonini G, Violi F
机构信息
Istituto di I Clinica Medica, University of Rome, Italy.
出版信息
Stroke. 1993 Mar;24(3):368-70. doi: 10.1161/01.str.24.3.368.
BACKGROUND AND PURPOSE
Our purpose was to assess the presence of lupus anticoagulant and fibrinolytic system abnormalities in young patients with stroke.
METHODS
We studied 33 consecutive ischemic patients aged < 50 years. Lupus anticoagulant was screened by four different coagulation tests, and the fibrinolytic system was studied by analyzing tissue plasminogen activator antigen and plasminogen activator inhibitor activity.
RESULTS
Six patients (18%), two of whom were affected by systemic lupus erythematosus, had lupus anticoagulant. Plasminogen activator inhibitor activity was significantly higher in those positive for lupus anticoagulant than in those negative for lupus anticoagulant and control subjects (p < 0.001).
CONCLUSIONS
In young patients with stroke, lupus anticoagulant is associated with an imbalance of the fibrinolytic system as a result of higher levels of plasminogen activator inhibitor.
背景与目的
我们的目的是评估年轻卒中患者中狼疮抗凝物和纤溶系统异常的存在情况。
方法
我们研究了33例年龄小于50岁的连续缺血性患者。通过四种不同的凝血试验筛查狼疮抗凝物，并通过分析组织纤溶酶原激活物抗原和纤溶酶原激活物抑制剂活性来研究纤溶系统。
结果
6例患者（18%）存在狼疮抗凝物，其中2例患有系统性红斑狼疮。狼疮抗凝物阳性患者的纤溶酶原激活物抑制剂活性显著高于狼疮抗凝物阴性患者和对照组（p < 0.001）。
结论
在年轻卒中患者中，由于纤溶酶原激活物抑制剂水平较高，狼疮抗凝物与纤溶系统失衡有关。
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