Thordsen S, Madsen C, Rosendahl L
Neuromedicinsk afdeling, Esbjerg Centralsygehus.
Ugeskr Laeger. 1993 Mar 1;155(9):628-30.
Over a period of 18 months, 155 patients with indications for lumbar puncture (LBP) on account of neurologic symptoms were examined for specific antibodies to Borrelia burgdorferi (BB) in the serum and for production of specific antibodies against BB in the cerebro-spinal fluid (CSF). Positive anti-BB-antibody-production in CSF was found in one patient and the clinical manifestations were consistent with the third stage of neuroborreliosis (NB). Three patients with NB as a tentative diagnosis were found negative for anti-BB-antibody-production in the CSF, and a clinical reevaluation excluded NB as a final diagnosis. The study showed a very high predictive value of the test for anti-BB-antibody-production in the CSF both with positive and negative results. The results suggest further that NB is of a low incidence in Denmark and not often misdiagnosed in favour of more well known diseases.
在18个月的时间里，对155例因神经症状而有腰椎穿刺指征的患者进行了血清中抗伯氏疏螺旋体（BB）特异性抗体以及脑脊液（CSF）中抗BB特异性抗体产生情况的检测。在1例患者的脑脊液中发现了阳性抗BB抗体产生，其临床表现与神经型莱姆病（NB）的第三阶段相符。3例初步诊断为NB的患者脑脊液中抗BB抗体产生检测为阴性，临床重新评估排除NB作为最终诊断。该研究表明，脑脊液中抗BB抗体产生检测无论结果为阳性还是阴性都具有很高的预测价值。结果进一步表明，NB在丹麦发病率较低，且不常被误诊为更常见的疾病。
