Thornbury K D, Harty H R, McGeown J G, McHale N G
Department of Physiology, School of Biomedical Science, Queen's University, Belfast, Northern Ireland, United Kingdom.
Am J Physiol. 1993 Feb;264(2 Pt 2):H604-10. doi: 10.1152/ajpheart.1993.264.2.H604.
The main mesenteric lymph duct was cannulated in halothane-anesthetized sheep, and continuous recordings were made of lymph flow, lymphatic pressure fluctuations, and arterial pressure. Stimulation of the left greater splanchnic nerve at frequencies of 1, 4, and 10 Hz caused lymph flow to increase by 30 +/- 9, 74 +/- 19, and 80 +/- 21%, respectively. Lymphatic contraction frequency and mean arterial pressure showed graded increases in response to increasing stimulus frequencies. These responses were reduced after intravenous infusion of phentolamine, suggesting that they were mediated by alpha-adrenoceptors. Lymph protein concentration remained unchanged during stimulation, suggesting that lymph formation in the nodes was not responsible for the increased lymph flow. The lymph flow response during 20 min of stimulation was biphasic, showing an initial transient increase followed by a depression to 45% of control. It is concluded that the initial increase in flow may be explained by stimulation of the lymphatic pump by nerves and/or circulating catecholamines, while the subsequent decrease reflected a reduction in lymph formation.
在氟烷麻醉的绵羊身上，对肠系膜主淋巴管进行插管，并连续记录淋巴流量、淋巴管压力波动和动脉血压。以1、4和10Hz的频率刺激左内脏大神经，导致淋巴流量分别增加30±9%、74±19%和80±21%。随着刺激频率增加，淋巴管收缩频率和平均动脉压呈分级增加。静脉注射酚妥拉明后，这些反应减弱，表明它们是由α-肾上腺素能受体介导的。刺激期间淋巴蛋白浓度保持不变，表明淋巴结中的淋巴生成与淋巴流量增加无关。刺激20分钟期间的淋巴流量反应呈双相，最初出现短暂增加，随后降至对照值的45%。结论是，最初的流量增加可能是由神经和/或循环儿茶酚胺刺激淋巴泵所致，而随后的减少反映了淋巴生成的减少。
