Gandham S B, Spaeth G L, Di Leonardo M, Costa V P
Glaucoma Service, Wills Eye Hospital, Philadelphia, Pa.
Arch Ophthalmol. 1993 Mar;111(3):370-2. doi: 10.1001/archopht.1993.01090030088045.
To our knowledge, this is the first histopathologic report of skin eruptions due to oral methazolamide. From the four cases studied, we conclude that there are at least two histopathologic types: one is characterized by perivascular lymphocytic infiltrate with a vacuolar alteration at the dermoepidermal junction, the other by perivascular eosinophils, lymphocytes, and scattered mast cells. There also seem to be at least two patterns of skin eruptions: one maculopapular and the other urticarial. The type of skin eruption and the histopathologic type appear to be related.
据我们所知，这是第一份关于口服甲唑酰胺引起皮肤疹的组织病理学报告。从所研究的四个病例来看，我们得出结论，至少有两种组织病理学类型：一种以真皮表皮交界处的血管周围淋巴细胞浸润伴空泡样改变为特征，另一种以血管周围嗜酸性粒细胞、淋巴细胞和散在的肥大细胞为特征。皮肤疹似乎也至少有两种类型：一种是斑丘疹，另一种是荨麻疹。皮肤疹的类型与组织病理学类型似乎相关。
