混合单倍型与自身免疫
Mixed haplotypes and autoimmunity.
作者信息
Nygard N R, McCarthy D M, Schiffenbauer J, Schwartz B D
机构信息
Beirne Carter Center, Health Sciences Center, University of Virginia, Charlottesville 22908.
出版信息
Immunol Today. 1993 Feb;14(2):53-6. doi: 10.1016/0167-5699(93)90058-s.
PMID:8447933
Abstract
Why do (NZB x NZW)F1 mice develop an autoimmune lupus-like syndrome? The second exons of the class II genes of NZB and NZW are identical to their counterparts of H-2d and H-2u haplotypes. Several lines of evidence suggest that this allows the production of a mixed haplotype molecule, I-E alpha dE beta z, and that this molecule plays a key role in the development of autoimmunity.
摘要
为什么（NZB×NZW）F1小鼠会患上自身免疫性狼疮样综合征？NZB和NZW的II类基因的第二个外显子与其H-2d和H-2u单倍型的对应物相同。几条证据表明，这使得能够产生一种混合单倍型分子I-EαdEβz，并且该分子在自身免疫的发展中起关键作用。
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