Factor E M, Mayer A D, Rosenblatt J S
Institute of Animal Behavior, Rutgers University, Newark, New Jersey 07102.
Behav Neurosci. 1993 Feb;107(1):166-85. doi: 10.1037//0735-7044.107.1.166.
Bilateral peripeduncular (PPN) lesions made on the seventh postpartum day (L7) with either radiofrequency (RF) current or N-methyl-d,l-aspartic acid (NMDA)/phosphate buffered saline (PBS) reduced maternal aggression (MA) and partially inhibited lactation without producing significant deficits in other items of maternal behavior (MB). RF-PPN lesions did not interfere with prolactin secretion, which suggests that there was deficient oxytocinergic activity. The deficit in MA was not due to interruption of afferent suckling input to the PPN: either thelectomizing females (day L6) or producing bilateral knifecuts in the mesencephalon (placed caudal to the level of the PPN; Day L7) had no effect on MA, but both procedures impaired lactation. Deficits in MA produced by RF-PPN lesions developed gradually between Days L4 and L7; lesions made either prepartum or on Day L1 did not impair MA or MB. Deficits in lactation first appeared after RF-PPN lesions on Day L1.
在产后第7天（L7）通过射频（RF）电流或N-甲基-D，L-天冬氨酸（NMDA）/磷酸盐缓冲盐水（PBS）造成双侧脚周核（PPN）损伤，可降低母性行为（MA），并部分抑制泌乳，而不会在其他母性行为（MB）项目中产生明显缺陷。射频-PPN损伤不会干扰催乳素分泌，这表明存在催产素能活性不足。母性行为的缺陷并非由于传入PPN的哺乳输入中断：在L6天切除乳头或在中脑（位于PPN水平尾侧；L7天）进行双侧刀切对母性行为均无影响，但这两种操作均会损害泌乳。射频-PPN损伤导致的母性行为缺陷在L4天至L7天之间逐渐出现；产前或L1天进行的损伤不会损害母性行为或其他母性行为。泌乳缺陷在L1天射频-PPN损伤后首次出现。
