通过原位杂交定位发现，大鼠空肠绒毛上的肠上皮细胞而非隐窝中的肠上皮细胞拥有M3毒蕈碱受体的m3 mRNA。
Enterocytes on rat jejunal villi but not in the crypts posses m3 mRNA for the M3 muscarinic receptor localized by in situ hybridization.
作者信息
Przyborski S A, Levin R J
机构信息
Department of Biomedical Science, University of Sheffield.
出版信息
Exp Physiol. 1993 Jan;78(1):109-12. doi: 10.1113/expphysiol.1993.sp003666.
Localization of m3 mRNA, for the expression of the M3 muscarinic receptor, along the crypt-villus axis, was undertaken in rat jejunum by in situ hybridization. While enterocytes on the lower two-thirds of the villi showed the presence of m3 mRNA it was absent in the crypt enterocytes. This indicates that the final locus of muscarinically activated jejunal secretion is mediated by the M3 receptor on the enterocytes of the villi and not via the crypt cells.
通过原位杂交技术，在大鼠空肠中对M3毒蕈碱受体表达的m3信使核糖核酸（mRNA）沿隐窝-绒毛轴进行定位。虽然绒毛下三分之二处的肠上皮细胞显示存在m3 mRNA，但隐窝肠上皮细胞中不存在。这表明毒蕈碱激活的空肠分泌的最终位点是由绒毛肠上皮细胞上的M3受体介导的，而非通过隐窝细胞。
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