细胞骨架突变体的表型

Phenotypes of cytoskeletal mutants.

作者信息

Brown S S

机构信息

Department of Anatomy and Cell Biology, University of Michigan Medical School, Ann Arbor 48109-0616.

出版信息

Curr Opin Cell Biol. 1993 Feb;5(1):129-34. doi: 10.1016/s0955-0674(05)80018-3.

DOI:10.1016/s0955-0674(05)80018-3

PMID:8448025

Abstract

Phenotypic studies continue to contribute to an understanding of the functions of cytoskeletal proteins. Many of these studies indicate some degree of functional redundancy within a family of cytoskeletal proteins. Some surprises have emerged, such as suggestions of unexpected relationships between the actin and microtubule cytoskeletons. Finally, phenotypic studies have provided evidence for a function of intermediate filaments.

摘要

表型研究继续有助于人们理解细胞骨架蛋白的功能。许多此类研究表明，细胞骨架蛋白家族内存在一定程度的功能冗余。一些令人惊讶的情况已经出现，比如肌动蛋白和微管细胞骨架之间存在意想不到的关系。最后，表型研究为中间丝的功能提供了证据。