Blouin R, Chaudhary I, Nishihara K, Cox S
College of Pharmacy, University of Kentucky, Lexington 40536-0082.
Br J Clin Pharmacol. 1993 Jan;35(1):62-4.
Stereoselectivity in the serum binding of flurbiprofen, a non-steroidal anti-inflammatory drug which is highly bound to albumin, was studied in patients with liver and renal disease. Subjects with renal disease or liver disease with ascites had significantly lower serum albumin concentrations than normals, resulting in higher free fractions of both the R(-) and S(+) enantiomers of flurbiprofen as determined by equilibrium dialysis. The ratio (+/- s.d.) of R/S-flurbiprofen free fractions was lower in the subjects with ascites (0.714 +/- 0.298) than in those without ascites (0.796 +/- 0.090) (P < 0.05).
对一种与白蛋白高度结合的非甾体抗炎药氟比洛芬在血清中的结合立体选择性进行了研究，研究对象为患有肝脏和肾脏疾病的患者。患有肾脏疾病或伴有腹水的肝脏疾病患者的血清白蛋白浓度显著低于正常人，通过平衡透析测定，这导致氟比洛芬的R(-)和S(+)对映体的游离分数均较高。伴有腹水的受试者中R/S-氟比洛芬游离分数的比值（±标准差）（0.714±0.298）低于无腹水的受试者（0.796±0.090）（P<0.05）。
