大鼠前速激肽原基因5'侧翼DNA序列；对假定转录因子结合位点的分析。
The sequence of 5' flanking DNA from the rat preprotachykinin gene; analysis of putative transcription factor binding sites.
作者信息
Chapman K, Lyons V, Harmar A J
机构信息
MRC Brain Metabolism Unit, Royal Edinburgh Hospital, UK.
出版信息
Biochim Biophys Acta. 1993 Mar 20;1172(3):361-3. doi: 10.1016/0167-4781(93)90233-4.
The rat preprotachykinin A (rPPT-A) gene is expressed in restricted populations of neurons and endocrine cells, including a subset of dorsal root ganglion (DRG) neurons. As part of a study to investigate the DNA sequences responsible for tissue-specific expression of the gene, we have determined the sequence of the 5' flanking DNA to 3350 bp upstream of the transcription start site. The sequenced region encodes a number of putative transcription factor binding sites which may play important roles in the regulation of rPPT-A gene transcription.
大鼠前速激肽原A（rPPT-A）基因在特定的神经元和内分泌细胞群体中表达，包括背根神经节（DRG）神经元的一个子集。作为研究负责该基因组织特异性表达的DNA序列的一部分，我们确定了转录起始位点上游3350 bp的5'侧翼DNA序列。测序区域编码了许多假定的转录因子结合位点，这些位点可能在rPPT-A基因转录的调控中发挥重要作用。
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