在2-3个抗原不相匹配的骨髓移植中，经体外药理学调节后的骨髓移植物抗宿主病和排斥反应发生率较低。
Low incidence of GvHD and rejection after pharmacological ex vivo modulation of bone marrow in 2-3 antigens mismatched BMT.
作者信息
de Manzini A, Andolina M, Agosti E, Giorgi R, Locatelli F, Bonetti L, Miniero R, Busca A, Porta F, Lanfranchi A
机构信息
Department of Pediatrics, Trieste, Italy.
出版信息
Bone Marrow Transplant. 1993;11 Suppl 1:114-6.
2-3 antigens mismatched BMT were performed on 32 children without a matched sibling donor. In the light of previous in vitro studies, which suggested a role of Vincristine and Methilprednisolone ex vivo treatment in modulating alloreactivity of T cells, bone marrow was treated with such a pharmacological cocktail before being infused. Acute GVHD 2 degrees to 4 degrees degree occurred in 46% of cases, chronic GVHD in 28%, graft failure in 13%. There was no significant difference between 2- and 3-antigens mismatched BMT as far as GVHD and graft failure are concerned.
对32名没有匹配同胞供体的儿童进行了2-3个抗原不匹配的骨髓移植。鉴于先前的体外研究表明长春新碱和甲基强的松龙体外处理在调节T细胞同种异体反应性中起作用，骨髓在输注前用这种药物组合进行处理。46%的病例发生了2至4度的急性移植物抗宿主病，28%发生了慢性移植物抗宿主病，13%发生了移植失败。就移植物抗宿主病和移植失败而言，2个和3个抗原不匹配的骨髓移植之间没有显著差异。
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