氟西汀与匹莫齐特之间可能存在相互作用，导致窦性心动过缓。

Possible interaction between fluoxetine and pimozide causing sinus bradycardia.

作者信息

Ahmed I, Dagincourt P G, Miller L G, Shader R I

机构信息

Department of Psychiatry, John A. Burns School of Medicine, University of Hawaii.

出版信息

Can J Psychiatry. 1993 Feb;38(1):62-3. doi: 10.1177/070674379303800116.

DOI:10.1177/070674379303800116

PMID:8448725

Abstract

Fluoxetine has been reported to have interactions with antipsychotics and other antidepressants with symptoms of toxicity of these drugs. We report a case of a possible interaction with pimozide which led to a potentially life threatening bradycardia. Careful monitoring should be done when these two drugs are prescribed at the same time, especially in the elderly and in patients with cardiac disease.

摘要

据报道，氟西汀与抗精神病药物及其他抗抑郁药物存在相互作用，可出现这些药物的中毒症状。我们报告了1例与匹莫齐特可能存在相互作用的病例，该相互作用导致了可能危及生命的心动过缓。当同时开具这两种药物时，应进行仔细监测，尤其是在老年人和患有心脏疾病的患者中。