Katoh T, Sato K, Kawamura M, Iwata H, Miura T
Department of Orthopaedic Surgery, Nagoya University School of Medicine, Japan.
Clin Orthop Relat Res. 1993 Feb(287):266-75.
Bone morphogenetic protein (BMP) was combined with true bone ceramic (TBC) in an attempt to produce a bone grafting material possessing the cancellous structure, osteoconductivity, and osteoinductivity of biologic bone. To determine the osteogenetic ability of this material (BMP-TBC) within bone marrow, BMP-TBC and TBC alone were implanted in the femoral condyles of Japanese White rabbits, and histographs of these implants, taken serially, were compared. Woven bone formation was observed both at the periphery and within surface pores of the BMP-TBC implants one week after implantation; these implants thus became secured to the host bone bed at an earlier stage than did TBC alone. The amount of new bone formation increased at a significantly higher rate with BMP-TBC than with TBC alone during the first four weeks. Therefore the BMP in BMP-TBC implants acts at an early stage on BMP-responding cells entering the pores of the TBC. These data also suggest that TBC, as a carrier for BMP, provides a favorable environment for the promotion of new bone formation.
骨形态发生蛋白（BMP）与真骨陶瓷（TBC）相结合，试图制备一种具有松质结构、骨传导性和骨诱导性的生物骨移植材料。为了确定这种材料（BMP-TBC）在骨髓中的成骨能力，将BMP-TBC和单独的TBC植入日本白兔的股骨髁，并对这些植入物的连续组织切片进行比较。植入后一周，在BMP-TBC植入物的周边和表面孔隙内均观察到编织骨形成；因此，这些植入物比单独的TBC更早地固定在宿主骨床上。在最初四周内，BMP-TBC组新骨形成量的增加速度明显高于单独使用TBC组。因此，BMP-TBC植入物中的BMP在早期作用于进入TBC孔隙的BMP反应细胞。这些数据还表明，TBC作为BMP的载体，为促进新骨形成提供了有利环境。
