山羊血浆蛋白酶抑制剂——II. 遗传分析

Caprine plasma proteinase inhibitors--II. Genetic analysis.

Vankan D M, Bell K

Department of Physiology and Pharmacology, University of Queensland, St Lucia, Brisbane, Australia.

Comp Biochem Physiol B. 1993 Jan;104(1):109-13. doi: 10.1016/0305-0491(93)90345-6.

Abstract

Analysis of the inheritances of the variants of five caprine plasma proteinase inhibitor systems in families demonstrated a genetic control of codominant alleles at five loci. 2. The PIA, B, C, D and E proteins are controlled by four (PIA1,2,3,4), three (PIB1,4,0), three (PIC2,3,0), five (PID1,2,3,4,0) and two (PIE1,2) alleles respectively. Null alleles were postulated for the PIB, PIC and PID systems. 3. The frequencies of the alleles differed substantially between the Australian and Texan Angoras and Cashmere breeds of goats. 4. The combined exclusion probability for the five PI systems was as high as 0.82 in the Cashmere breed, indicating the potential of the proteinase inhibitor proteins for parentage control purposes.

摘要

对家族中五个山羊血浆蛋白酶抑制剂系统变体的遗传分析表明，五个位点上的共显性等位基因存在遗传控制。2. PIA、B、C、D和E蛋白分别由四个（PIA1、2、3、4）、三个（PIB1、4、0）、三个（PIC2、3、0）、五个（PID1、2、3、4、0）和两个（PIE1、2）等位基因控制。推测PIB、PIC和PID系统存在无效等位基因。3. 澳大利亚安哥拉山羊、德克萨斯安哥拉山羊和克什米尔山羊品种之间的等位基因频率存在显著差异。4. 在克什米尔山羊品种中，五个PI系统的联合排除概率高达0.82，表明蛋白酶抑制剂蛋白在亲子鉴定方面具有潜力。