Ulloa M A, Merchan E C
Department of Orthopaedics and Traumatology, La Paz Hospital, Madrid, Spain.
Int Orthop. 1993;17(1):60-3. doi: 10.1007/BF00195228.
Two hundred and sixty-nine patients with breast cancer were assessed with regard to multiple parameters at the time of initial diagnosis. Over a follow-up period of 6 or 7 years, 84 patients developed skeletal metastases and in 42 they were symptomatic. Symptomatic bone metastases were related to lytic metastases and an elevated sedimentation rate. The significant parameters predisposing to the development of bone metastases were the presence of adenopathies or metastases at the time of initial diagnosis. The number of axillary nodes involved was related to the number of bone metastases, the number of spontaneous abortions, and the gonadal endocrine function. The adherence of axillary nodes was related to the number of bone metastases, an elevated sedimentation rate and the serum calcium level.
269例乳腺癌患者在初诊时就多个参数进行了评估。在6或7年的随访期内，84例患者发生了骨转移，其中42例出现症状。有症状的骨转移与溶骨性转移及血沉升高有关。易发生骨转移的重要参数是初诊时存在腺病或转移。腋窝淋巴结受累数目与骨转移数目、自然流产次数及性腺内分泌功能有关。腋窝淋巴结粘连与骨转移数目、血沉升高及血清钙水平有关。
