Spiegelmann R, Friedman W A, Bova F J, Theele D P, Mickle J P
Department of Neurosurgery, University of Florida, Gainesville.
J Neurosurg. 1993 Apr;78(4):638-44. doi: 10.3171/jns.1993.78.4.0638.
Fifteen cats were irradiated with an animal LINAC (linear accelerator) radiosurgery device. After 6 months, they were studied with gadolinium-enhanced magnetic resonance (MR) imaging, gross pathology after Evans blue perfusion, and histopathology. The lesion size was relatively constant in the cats receiving a dose of 7500, 10,000, 12,500, or 15,000 cGy to the 84% isodose line of a 1-cm collimator. The composition of the lesion correlated with dose: the lower-dose lesions were found histologically to contain areas of edema, demyelination, reactive gliosis, and vascular proliferation; the higher-dose lesions contained increasing amounts of hemorrhage and coagulative necrosis. The borders of the lesions were sharply demarcated from surrounding normal brain. Gadolinium-enhanced MR studies correlated well with areas of blood-brain barrier breakdown, as confirmed by areas of Evans blue staining. This model could serve as the basis for further studies of the biological effects of LINAC radiosurgery.
用一台动物直线加速器放射外科设备对15只猫进行照射。6个月后，对它们进行钆增强磁共振成像、伊文思蓝灌注后的大体病理学以及组织病理学研究。在接受1厘米准直器84%等剂量线7500、10000、12500或15000厘戈瑞剂量照射的猫中，病变大小相对恒定。病变的组成与剂量相关：组织学检查发现低剂量病变包含水肿、脱髓鞘、反应性胶质增生和血管增生区域；高剂量病变包含越来越多的出血和凝固性坏死。病变边界与周围正常脑组织界限分明。钆增强磁共振研究与血脑屏障破坏区域相关性良好，伊文思蓝染色区域证实了这一点。该模型可作为进一步研究直线加速器放射外科生物学效应的基础。
