Galløe A M, Graudal N, Møller J, Bro H, Jørgensen M, Christensen H R
Department of Internal Medicine P/chest clinic, Bispebjerg Hospital, Copenhagen, Denmark.
J Hum Hypertens. 1993 Feb;7(1):43-5.
It has been claimed that calcium lowers BP. The present randomised, double-blind, placebo-controlled crossover study is the first to investigate the effect on BP of a high oral dose of calcium given for a long period to patients with previously untreated hypertension. Elemental calcium (2 g) was administered for 12 weeks interchanging with a period of 12 weeks of placebo. Twenty patients completed the protocol. There was no significant difference in change of BP during the period of additional calcium intake when compared with placebo (P = 0.33). The risk of not detecting a real BP-lowering effect of calcium of at least 3 mmHg was < 5%. No evidence for the existence of a subgroup of 'responders' was found. It is concluded that a high daily dose of calcium supplementation given for 12 weeks does not decrease BP in previously untreated patients with mild to moderate hypertension.
据称钙可降低血压。本随机、双盲、安慰剂对照交叉研究首次调查了长期给予高口服剂量钙对未经治疗的高血压患者血压的影响。给予元素钙（2克）12周，期间穿插12周的安慰剂期。20名患者完成了该方案。与安慰剂相比，额外补钙期间血压变化无显著差异（P = 0.33）。未检测到钙至少降低3 mmHg血压的真实效果的风险<5%。未发现存在“反应者”亚组的证据。结论是，在12周内每日给予高剂量钙补充剂对未经治疗的轻至中度高血压患者的血压没有降低作用。
