Hirsch I B, Farkas-Hirsch R
University of Washington Diabetes Care Center, Seattle.
Nurs Clin North Am. 1993 Mar;28(1):9-23.
Intensive insulin therapy is composed of an entire therapeutic program of diabetes management. One component of that program is a multiple-component insulin regimen. There are several important pharmacokinetic issues that must be appreciated when prescribing insulin. These include differences in absorption characteristics between animal and human insulin, variations in intraindividual insulin absorption, the influence of injection sites on insulin absorption, and lag time. Only physiologic insulin regimens should be used in patients with type I diabetes, and there are advantages and disadvantages to the various available options. There are theoretic reasons why CSII may be better for many patients. Finally, the nurse specialist/educator who is initiating the insulin therapy should be familiar with the general guidelines for the various insulin regimens in addition to implementing appropriate diabetes algorithms.
强化胰岛素治疗由一整套糖尿病管理治疗方案组成。该方案的一个组成部分是多组分胰岛素治疗方案。在开具胰岛素处方时，有几个重要的药代动力学问题必须予以重视。这些问题包括动物胰岛素与人胰岛素在吸收特性上的差异、个体内胰岛素吸收的变化、注射部位对胰岛素吸收的影响以及延迟时间。1型糖尿病患者应仅使用生理性胰岛素治疗方案，各种可用选项都有其优缺点。从理论上讲，持续皮下胰岛素输注（CSII）对许多患者可能更好。最后，启动胰岛素治疗的专科护士/教育工作者除了实施适当的糖尿病治疗算法外，还应熟悉各种胰岛素治疗方案的一般指南。
