洛伐他汀增强了通过低密度脂蛋白递送至HT29人结肠腺癌细胞的卟吩姆钠的光细胞毒性作用。

Lovastatin potentiates the photocytotoxic effect of photofrin II delivered to HT29 human colonic adenocarcinoma cells by low density lipoprotein.

作者信息

Biade S, Mazière J C, Mora L, Santus R, Mazière C, Auclair M, Morlière P, Dubertret L

机构信息

Laboratoire de Physico-Chimie de l'Adaptation Biologique, INSERM U312, Muséum National d'Histoire Naturelle de Paris, France.

出版信息

Photochem Photobiol. 1993 Feb;57(2):371-5. doi: 10.1111/j.1751-1097.1993.tb02303.x.

DOI:10.1111/j.1751-1097.1993.tb02303.x

PMID:8451300

Abstract

A 24 h preculture of HT29-18 human colonic adenocarcinoma cells with the sterol synthesis inhibitor lovastatin at concentrations of 0.1-0.5 microM markedly increased the photocytotoxic effect of photofrin II delivered to cells by low density lipoproteins. Under the same conditions, LDL binding and photofrin II (PII) uptake by HT29 cells increased about 1.8-fold and 1.5-fold, respectively. These results suggest that hydroxymethylglutaryl-coenzyme A reductase inhibitors could be useful for potentiating the photodynamic therapy of tumors by PII.

摘要

将人结肠腺癌细胞HT29 - 18与浓度为0.1 - 0.5微摩尔的固醇合成抑制剂洛伐他汀进行24小时预培养，可显著增强通过低密度脂蛋白递送至细胞的卟啉钠的光细胞毒性作用。在相同条件下，HT29细胞对低密度脂蛋白的结合及对卟啉钠（PII）的摄取分别增加了约1.8倍和1.5倍。这些结果表明，羟甲基戊二酰辅酶A还原酶抑制剂可能有助于增强卟啉钠对肿瘤的光动力治疗效果。