Brownlow B S, Park C R, Schwartz R S, Woods S C
Department of Psychology, University of Washington, Seattle 98195.
Physiol Behav. 1993 Mar;53(3):421-4. doi: 10.1016/0031-9384(93)90133-z.
The present study was designed to assess whether the pattern of meal feeding and the degree of caloric restriction have an effect on the body weights and refeeding patterns of restricted 4-month-old Long-Evans rats, relative to ad lib-fed controls. Four experimental groups of rats (n = 6 each) were put on different paradigms of food restriction, and a fifth group fed ad lib throughout served as controls. Twelve rats were restricted to receiving 50% of their mean baseline food intake, and 12 rats received only 70% of their baseline food intake. Each experimental group was further subdivided with one subgroup receiving all of their calories in one meal/day and the other with caloric intake equally divided into two meals/day. There was no statistical difference in the final body weights of the restricted groups. Although there appeared to be identical patterns of weight regain, none of the restricted groups ever reached the mean body weight of the controls because of an asymptotic leveling off of rate of body weight regain. Rats that had received 50% of baseline calories as two meals/day had significantly more adipose mass than did any other group. The present findings suggest that in the rat, refeeding and, hence, regulation, occurs to normalize rate of weight gain rather than absolute body weight.
本研究旨在评估相对于自由进食的对照组，进餐模式和热量限制程度是否会对4个月大的限食Long-Evans大鼠的体重及再喂养模式产生影响。将四组实验大鼠（每组n = 6）置于不同的食物限制模式下，第五组大鼠全程自由进食作为对照组。12只大鼠被限制摄入其平均基线食物摄入量的50%，另外12只大鼠仅摄入其基线食物摄入量的70%。每个实验组进一步细分为两个亚组，一个亚组每天一餐摄入全部热量，另一个亚组每天两餐平均分配热量摄入。限食组的最终体重没有统计学差异。尽管体重恢复模式似乎相同，但由于体重恢复率逐渐趋于平稳，没有一个限食组达到对照组的平均体重。每天分两餐摄入50%基线热量的大鼠比其他任何组的脂肪量都显著更多。目前的研究结果表明，在大鼠中，再喂养以及由此产生的调节作用是为了使体重增加率正常化，而非绝对体重。
