[静脉输注脂肪乳剂对家兔离体肺液体滤过率及肺动脉压力的影响]
[Effect of the administration of intralipid on liquid filtration rate and pressure of the pulmonary artery in isolated lung of rabbits].
作者信息
Pozo-Parilli J C, Pinto-Plata V M, Martínez-Ruiz R, Guevara M E, Sánchez de León R
机构信息
Unidad de Fisiología Respiratoria, Instituto de Medicina Experimental, Facultad de Medicina, Venezuela.
出版信息
Rev Esp Anestesiol Reanim. 1993 Mar-Apr;40(2):76-80.
INTRODUCTION
We study the effect on Intralipid on pulmonary circulation.
METHODS
A 10% infusion of Intralipid was administered at a dose of 0.5/kg in 14 isolated rabbit lungs in which constant blood flow infusion was carried out principally in zone 3. The liquid filtration rate (LFR) and the mean pressure of the pulmonary artery were measured.
RESULTS
A constant increase of mean pressure of the pulmonary artery was observed following the infusion (from 12.32 +/- 3.66 cm of H2O to 39.92 +/- 07.68 cmH2O (p < 0.01) which was associated to a significant increase in the rate of liquid filtration (from 0.018 +/- 0.01 g/min to 0.198 +/- 0.04 g/min; p < 0.01).
CONCLUSIONS
The administration of Intralipid produces a statistically significant increase of mean pressure of the pulmonary artery and the rate of liquid filtration. This is probably caused by vasoconstriction due to metabolic changes produced by Intralipid on pulmonary circulation.
引言
我们研究了脂肪乳剂对肺循环的影响。
方法
对14只离体兔肺以0.5/kg的剂量输注10%的脂肪乳剂，这些兔肺主要在3区进行恒定血流灌注。测量液体滤过率（LFR）和肺动脉平均压。
结果
输注后观察到肺动脉平均压持续升高（从12.32±3.66厘米水柱升至39.92±7.68厘米水柱；p<0.01），这与液体滤过率显著增加相关（从0.018±0.01克/分钟升至0.198±0.04克/分钟；p<0.01）。
结论
脂肪乳剂的输注使肺动脉平均压和液体滤过率在统计学上显著增加。这可能是由于脂肪乳剂对肺循环产生的代谢变化导致血管收缩所致。
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