兔IgA同种异型的血清学和结构比较。

Serologic and structural comparisons of rabbit IgA allotypes.

作者信息

Knight K L, Friedenson B, Hanly W C, Malek T R, Peterson B E

出版信息

Adv Exp Med Biol. 1978;107:513-22. doi: 10.1007/978-1-4684-3369-2_58.

Abstract

Serologic and structural comparisons of the rabbit IgA-g allotypes revealed that 1) the IgA-g allotypes have multiple allotypic determinant sites, 2) the g74, g76 and g77 allotypic specificities have several allotypic determinants in common whereas g75 molecules do not appear to have allotypic determinants in common with g74, g76 and g77 molecules, 3) the partial amino acid sequence of alpha chain from g75 and g76 Fc2alpha fragments differ by at least one amino acid residue, and 4) the g74 alpha-chains may have the "extra" intradomain disulfide bond in the Calpha2 domain whereas the g75 and g76 alpha chains lack this disulfide bond. Thus, multiple mutational events must have occurred during the evolution of g74, g75 and g77 genes.

摘要

对兔IgA-g同种异型的血清学和结构比较显示：1）IgA-g同种异型具有多个同种异型决定簇位点；2）g74、g76和g77同种异型特异性具有几个共同的同种异型决定簇，而g75分子似乎没有与g74、g76和g77分子共同的同种异型决定簇；3）g75和g76 Fc2α片段的α链部分氨基酸序列至少相差一个氨基酸残基；4）g74α链可能在Cα2结构域中有“额外”的结构域内二硫键，而g75和g76α链缺乏这种二硫键。因此，在g74、g75和g77基因的进化过程中一定发生了多次突变事件。