Feingold I B, Longhurst P A, Colby H D
Department of Pharmacology and Toxicology, Philadelphia College of Pharmacy and Science, PA 19104.
Biochim Biophys Acta. 1993 Mar 10;1176(1-2):192-6. doi: 10.1016/0167-4889(93)90196-v.
Previous studies demonstrated that alpha-tocopherol concentrations were far greater in adrenal glands and in livers from female rats than in those from males. Studies were done to investigate the role of androgens and estrogens in the regulation of adrenal and hepatic alpha-tocopherol content. In males and females, adrenal concentrations of alpha-tocopherol were approx. 10-fold greater than those in liver and the highest concentrations of alpha-tocopherol were in the crude mitochondrial fractions in both organs. Castration of female rats decreased alpha-tocopherol concentrations in adrenals and in livers. Proportionately similar declines occurred in both organs and in all subcellular fractions. The effects of castration were prevented by estradiol replacement at the time of surgery. Gonadectomy in male rats had effects opposite to those in females, increasing adrenal and hepatic alpha-tocopherol concentrations. Testosterone administration to castrated males prevented the increases in adrenal and hepatic alpha-tocopherol content. Neither castration nor gonadal hormone replacement in either sex had any effect on plasma alpha-tocopherol levels or on cytosolic ascorbic acid concentrations in adrenals or livers. The results indicate a role for estrogens and androgens in the regulation of adrenal and hepatic concentrations of alpha-tocopherol. The opposing effects of androgens and estrogens fully account for the sex differences in tissue alpha-tocopherol levels in rats.
先前的研究表明，雌性大鼠肾上腺和肝脏中的α-生育酚浓度远高于雄性大鼠。开展了多项研究以调查雄激素和雌激素在调节肾上腺和肝脏α-生育酚含量中的作用。在雄性和雌性大鼠中，肾上腺中的α-生育酚浓度约为肝脏中的10倍，且两个器官中α-生育酚浓度最高的是粗线粒体部分。切除雌性大鼠的卵巢会降低肾上腺和肝脏中的α-生育酚浓度。两个器官以及所有亚细胞部分均出现了成比例的类似下降。手术时用雌二醇替代可防止卵巢切除的影响。雄性大鼠去势产生的影响与雌性大鼠相反，会增加肾上腺和肝脏中的α-生育酚浓度。给去势雄性大鼠注射睾酮可防止肾上腺和肝脏中α-生育酚含量增加。无论雄性还是雌性，去势或性腺激素替代对血浆α-生育酚水平或肾上腺或肝脏中的胞质抗坏血酸浓度均无任何影响。结果表明雌激素和雄激素在调节肾上腺和肝脏中α-生育酚浓度方面发挥作用。雄激素和雌激素的相反作用充分解释了大鼠组织中α-生育酚水平的性别差异。
