Oliveri M B, Ladizesky M, Mautalen C A, Alonso A, Martinez L
Section Osteopatias Medicas, Hospital de Clinicas, Universidad de Buenos Aires, Argentina.
Bone Miner. 1993 Jan;20(1):99-108. doi: 10.1016/s0169-6009(08)80041-4.
Serum levels of calcium, phosphorus, alkaline phosphatase, 250HD, 1.25(OH)2D and PTH were studied in a group of 42 children aged 8.5 +/- 1.8 years (X +/- SD) from the city of Ushuaia (latitude 55 degrees S), at both the end of the winter and the end of summer. Calcium, phosphorus, alkaline phosphatase and 1.25(OH)2D serum levels were not different in summer and winter. The levels of serum 25OHD were significantly higher in summer (18.4 +/- 7.3 ng/ml) than in winter (9.8 +/- 3.8 ng/ml P < 0.001). The levels of 25OHD in children with fair or dark skin were similar in winter but were significantly higher in children with fair skin in summer (20.0 +/- 7.2 ng/l vs 15.3 +/- 5.1 ng/ml (P < 0.05). Serum levels of PTH were higher in winter (58.2 +/- 30.5 pg/ml) than in summer (47.9 +/- 28.3 pg/ml) (P < 0.03). The results demonstrate the existence of a population with low serum levels of 25OHD in winter. The higher levels of PTH in winter when serum 25OHD levels are lower could be the cause of the lack of seasonal variation in serum calcium and 1.25(OH)2D levels. Further studies are needed to establish whether these changes besides increasing the incidence of rickets, could also affect the mineral density of the skeleton in the population of this vitamin-D-deficient area.
对来自乌斯怀亚市（南纬55度）的一组42名年龄在8.5±1.8岁（X±SD）的儿童，在冬季末和夏季末研究了血清钙、磷、碱性磷酸酶、250HD、1,25(OH)2D和甲状旁腺激素（PTH）水平。夏季和冬季的钙、磷、碱性磷酸酶和1,25(OH)2D血清水平无差异。血清25OHD水平夏季（18.4±7.3 ng/ml）显著高于冬季（9.8±3.8 ng/ml，P<0.001）。肤色浅或深的儿童冬季25OHD水平相似，但夏季肤色浅的儿童25OHD水平显著更高（20.0±7.2 ng/l对15.3±5.1 ng/ml，P<0.05）。血清PTH水平冬季（58.2±30.5 pg/ml）高于夏季（47.9±28.3 pg/ml）（P<0.03）。结果表明冬季存在血清25OHD水平低的人群。冬季血清25OHD水平较低时PTH水平较高，可能是血清钙和1,25(OH)2D水平缺乏季节性变化的原因。需要进一步研究以确定这些变化除了增加佝偻病发病率外，是否还会影响这个维生素D缺乏地区人群的骨骼矿物质密度。
