雄性白化大鼠中羟吲哚-O-甲基转移酶（HIOMT）活性存在明显的昼夜节律。
A distinct diurnal rhythm in hydroxyindole-O-methyltransferase (HIOMT) activity in the male albino rat.
作者信息
McLeod S D, Cairncross K D
机构信息
School of Biological Sciences, Macquarie University, North Ryde, New South Wales, Australia.
出版信息
Gen Comp Endocrinol. 1993 Feb;89(2):214-9. doi: 10.1006/gcen.1993.1026.
Pineal hydroxyindole-O-methyltransferase (HIOMT) has been reported to show a diurnal rhythm activity in the rat, although this is not fully confirmed. The present study reexamines this issue and reports a distinct diurnal rhythm in rat pineal HIOMT. Peak enzyme activity occurs 5 hr after the onset of darkness, followed by two lesser bursts of activity preceding each change in the photoperiod. The approximately 18-fold increase in methylating capacity at night represents the greatest variation in HIOMT activity thus far reported in the rat and may be attributed to the age, weight, and housing regimen of the animals used.
据报道，大鼠松果体中的羟基吲哚 - O - 甲基转移酶（HIOMT）呈现昼夜节律活动，尽管这一点尚未完全得到证实。本研究重新审视了这一问题，并报告了大鼠松果体HIOMT存在明显的昼夜节律。酶活性峰值出现在黑暗开始后5小时，随后在光周期每次变化之前有两次较小的活性爆发。夜间甲基化能力大约增加18倍，这是迄今为止报道的大鼠HIOMT活性最大的变化，可能归因于所用动物的年龄、体重和饲养方式。
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