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A群链球菌免疫球蛋白G结合蛋白的表达与小鼠皮肤感染模型中致病性的关联

Association between expression of immunoglobulin G-binding proteins by group A streptococci and virulence in a mouse skin infection model.

作者信息

Raeder R, Boyle M D

机构信息

Department of Microbiology, Medical College of Ohio, Toledo 43699-0008.

出版信息

Infect Immun. 1993 Apr;61(4):1378-84. doi: 10.1128/iai.61.4.1378-1384.1993.

DOI:10.1128/iai.61.4.1378-1384.1993
PMID:8454339
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC281374/
Abstract

In this study, we developed a mouse model of skin infection to test the association between expression of immunoglobulin-binding proteins by and infectivity of group A streptococci. Group A streptococci capable of crossing tissue barriers and establishing a lethal systemic infection in mice showed a higher level of immunoglobulin-binding protein expression. The group A streptococci recovered from the spleen of a mouse that died following a skin infection were found to be more virulent when injected into the skin of naive mice. Together, these results suggest that immunoglobulin-binding protein expression by group A streptococci correlates with their ability to establish invasive skin infections.

摘要

在本研究中，我们建立了一种皮肤感染小鼠模型，以测试A组链球菌免疫球蛋白结合蛋白的表达与其感染性之间的关联。能够穿越组织屏障并在小鼠中建立致死性全身感染的A组链球菌显示出更高水平的免疫球蛋白结合蛋白表达。从皮肤感染后死亡的小鼠脾脏中分离出的A组链球菌，当注射到未感染的小鼠皮肤中时，其毒性更强。这些结果共同表明，A组链球菌免疫球蛋白结合蛋白的表达与其建立侵袭性皮肤感染的能力相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0351/281374/7fb77007f84a/iai00016-0225-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0351/281374/216d78544178/iai00016-0223-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0351/281374/56d29109d4bd/iai00016-0224-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0351/281374/7fb77007f84a/iai00016-0225-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0351/281374/216d78544178/iai00016-0223-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0351/281374/56d29109d4bd/iai00016-0224-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0351/281374/7fb77007f84a/iai00016-0225-a.jpg

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本文引用的文献

1
Protein A of Staphylococcus aureus and related immunoglobulin receptors produced by streptococci and pneumonococci.金黄色葡萄球菌的A蛋白以及链球菌和肺炎球菌产生的相关免疫球蛋白受体。
Adv Immunol. 1982;32:157-252.
2
Effect of mouse passage on Fc receptor expression by group A streptococci.小鼠传代对A组链球菌Fc受体表达的影响。
Scand J Immunol. 1984 Nov;20(5):433-9. doi: 10.1111/j.1365-3083.1984.tb01022.x.
3
A rapid technique for measuring leukocyte chemotaxis in vivo.
J Immunol Methods. 1984 Apr 27;69(2):197-206. doi: 10.1016/0022-1759(84)90318-1.
序列元件富集分析确定细菌表型的遗传基础。
Nat Commun. 2016 Sep 16;7:12797. doi: 10.1038/ncomms12797.
4
Agitation down-regulates immunoglobulin binding protein EibG expression in Shiga toxin-producing Escherichia coli (STEC).激动状态下调产志贺毒素大肠杆菌（STEC）中免疫球蛋白结合蛋白EibG的表达。
PLoS One. 2015 Mar 6;10(3):e0119583. doi: 10.1371/journal.pone.0119583. eCollection 2015.
5
Novel Sample Preparation for Mass Spectral Analysis of Complex Biological Samples.复杂生物样品质谱分析的新型样品制备方法
Curr Proteomics. 2010 Jul;7(2):90-101. doi: 10.2174/157016410791330589.
6
Generation of metabolically diverse strains of Streptococcus pyogenes during survival in stationary phase.化脓性链球菌在稳定期存活期间代谢多样菌株的产生。
J Bacteriol. 2009 Oct;191(20):6242-52. doi: 10.1128/JB.00440-09. Epub 2009 Aug 7.
7
Streptococcus pyogenes infection in mouse skin leads to a time-dependent up-regulation of protein H expression.化脓性链球菌感染小鼠皮肤会导致蛋白质H表达随时间上调。
Infect Immun. 2003 Oct;71(10):6079-82. doi: 10.1128/IAI.71.10.6079-6082.2003.
8
MtsABC is important for manganese and iron transport, oxidative stress resistance, and virulence of Streptococcus pyogenes.MtsABC对化脓性链球菌的锰和铁运输、抗氧化应激能力及毒力至关重要。
Infect Immun. 2003 May;71(5):2656-64. doi: 10.1128/IAI.71.5.2656-2664.2003.
9
Mouse skin passage of a Streptococcus pyogenes Tn917 mutant of sagA/pel restores virulence, beta-hemolysis and sagA/pel expression without altering the position or sequence of the transposon.化脓性链球菌sagA/pel的Tn917突变体在小鼠皮肤传代后恢复了毒力、β溶血活性和sagA/pel表达，且未改变转座子的位置或序列。
BMC Microbiol. 2001;1:33. doi: 10.1186/1471-2180-1-33. Epub 2001 Dec 17.
10
Surface-expressed mig protein protects Streptococcus dysgalactiae against phagocytosis by bovine neutrophils.表面表达的mig蛋白可保护停乳链球菌免受牛中性粒细胞的吞噬作用。
Infect Immun. 2001 Oct;69(10):6030-7. doi: 10.1128/IAI.69.10.6030-6037.2001.
4
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.在噬菌体T4头部组装过程中结构蛋白的切割
Nature. 1970 Aug 15;227(5259):680-5. doi: 10.1038/227680a0.
5
Mast cells and local resistance to Russell's viper venom.
J Immunol. 1965 Nov;95(5):867-75.
6
Effects of staphylococcal protein A on heat labile opsonins.
J Immunol. 1974 Mar;112(3):1177-80.
7
Pathogenicity of Staphylococcus aureus mutants in general and local infections.金黄色葡萄球菌突变体在全身感染和局部感染中的致病性。
Acta Pathol Microbiol Scand B Microbiol Immunol. 1972;80(4):564-70. doi: 10.1111/j.1699-0463.1972.tb00180.x.
8
A surface glycoprotein of Trypanosoma lewisi binds immunoglobulin G from the serum of uninfected rats.路氏锥虫的一种表面糖蛋白可结合未感染大鼠血清中的免疫球蛋白G。
Infect Immun. 1986 Aug;53(2):420-6. doi: 10.1128/iai.53.2.420-426.1986.
9
Isolation and partial characterization of a type II Fc receptor from a group A streptococcus.从A群链球菌中分离并部分鉴定II型Fc受体
Mol Cell Biochem. 1986 Apr;70(1):57-66. doi: 10.1007/BF00233803.
10
Identification of protein A from Staphylococcus intermedius isolated from canine skin.
Am J Vet Res. 1988 May;49(5):697-701.