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Cross-linking of Fc gamma RIIIA on natural killer cells results in tyrosine phosphorylation of PLC-gamma 1 and PLC-gamma 2.

作者信息

Liao F, Shin H S, Rhee S G

机构信息

Department of Molecular Biology and Genetics, Johns Hopkins University, School of Medicine, Baltimore, MD 21205.

出版信息

J Immunol. 1993 Apr 1;150(7):2668-74.

PMID:8454849
Abstract

The Fc gamma RIIIA, which is composed of a transmembrane IgG-binding glycoprotein and either a disulfide-linked homodimer (zeta zeta, gamma gamma) or heterodimer (zeta gamma), mediates the antibody-dependent cellular cytotoxicity in NK cells. The role of phospholipase C (PLC) isozymes in Fc gamma RIIIA-mediated signal transduction was investigated. The NK cell line NK3.3 was found to contain PLC-gamma 1 and an especially high concentration of PLC-gamma 2, but PLC-beta 1 and PLC-delta 1 were not detected. Cross-linking of Fc gamma RIIIA on NK3.3 cells induced a rapid phosphorylation of PLC-gamma 1 and PLC-gamma 2 on tyrosine residues. Pretreatment of NK3.3 cells with a tyrosine kinase inhibitor, herbimycin A, prevented the tyrosine phosphorylation of both PLC-gamma 1 and PLC-gamma 2. These results indicate that activation of Fc gamma RIIIA on NK3.3 cells is coupled either directly or indirectly to a nonreceptor tyrosine kinase, which phosphorylates, and thereby activates PLC-gamma 1 and PLC-gamma 2.

摘要

相似文献

1
Cross-linking of Fc gamma RIIIA on natural killer cells results in tyrosine phosphorylation of PLC-gamma 1 and PLC-gamma 2.
J Immunol. 1993 Apr 1;150(7):2668-74.
2
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引用本文的文献

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Int Immunol. 2012 Dec;24(12):793-802. doi: 10.1093/intimm/dxs080. Epub 2012 Sep 7.
2
Distinct roles of phosphoinositide-3 kinase and phospholipase Cgamma2 in B-cell receptor-mediated signal transduction.磷酸肌醇-3激酶和磷脂酶Cγ2在B细胞受体介导的信号转导中的不同作用
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Herbimycin, a tyrosine kinase inhibitor with Src selectivity, reduces progesterone and estradiol secretion by human granulosa cells.
赫比霉素是一种具有Src选择性的酪氨酸激酶抑制剂，可减少人颗粒细胞分泌孕酮和雌二醇。
Endocrine. 2001 Aug;15(3):271-6. doi: 10.1385/ENDO:15:3:271.
4
Vav in natural killer cells is tyrosine phosphorylated upon cross-linking of Fc gamma RIIIA and is constitutively associated with a serine/threonine kinase.自然杀伤细胞中的Vav在FcγRIIIA交联后发生酪氨酸磷酸化，并与一种丝氨酸/苏氨酸激酶持续相关。
Biochem J. 1996 Sep 1;318 ( Pt 2)(Pt 2):527-32. doi: 10.1042/bj3180527.
5
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Proc Natl Acad Sci U S A. 1995 Aug 1;92(16):7381-5. doi: 10.1073/pnas.92.16.7381.