Schneider W P, Glaser S M, Kondas J A, Hakimi J
Protein Design Labs, Inc., Mountain View, CA 94043.
J Immunol. 1993 Apr 1;150(7):3086-90.
The anti-ld response developed by cynomolgus monkeys to the humanized anti-Tac antibody was analyzed by using 12 humanized anti-Tac variants differing in V region structure. The majority of the monkey response was directed against idiotopes composed wholly or in part of complementarity-determining regions H1, H2, and L3. There was no detectable response directed solely to five single complementarity-determining regions examined or solely to the modified human V region framework.
通过使用12种V区结构不同的人源化抗Tac抗体变体，分析了食蟹猴对人源化抗Tac抗体产生的抗独特型反应。大多数猴子的反应针对的是完全或部分由互补决定区H1、H2和L3组成的独特型表位。对于所检测的五个单一互补决定区或仅针对修饰后的人V区框架，均未检测到单独的反应。
