Fitzgerald R L, Fishel C E, Bush L L
Mass Spectrometry Laboratory, VA Hospital, San Diego, CA.
J Forensic Sci. 1993 Mar;38(2):477-83.
Reports on fatalities of chlorofluorocarbons usually involve chlorotrifluoroethane, trichlorofluoromethane, dichlorodifluoromethane or chlorodifluoromethane, where analysis was done using packed column gas chromatography. In this case a death was caused by an azeotropic mixture of chlorodifluoromethane and chloropentafluoroethane, a combination that has not previously been reported in the forensic literature. This report details the analysis using mass selective detection employing capillary gas chromatography columns currently used in many toxicology laboratories. Postmortem toxicology revealed blood concentrations of chlorodifluoromethane and chloropentafluoroethane of 71 mg/L and 0.30 mg/L, respectively. Brain, liver, and lung concentrations of chlorodifluoromethane were (mg/kg) 2.8, 4.4, and 1.6, respectively. Brain, liver, and lung concentrations of chloropentafluoroethane were (mg/kg) 0.80, 0.80, and 0.11, respectively. The victim's blood contained 5.5 mg/L caffeine. Lidocaine, used in resuscitation attempts, was also present in the victim's blood. No other alkali-extractable drugs or volatile alcohols were detected in the victim's blood. The cause of death was acute respiratory arrest due to chlorofluorocarbon inhalation.
关于氯氟烃致死的报告通常涉及三氯氟乙烷、三氯氟甲烷、二氯二氟甲烷或氯二氟甲烷，这些案例中的分析是使用填充柱气相色谱法进行的。在此案例中，死亡是由氯二氟甲烷和氯五氟乙烷的共沸混合物导致的，这种组合在法医文献中此前尚未有过报道。本报告详细介绍了使用目前许多毒理学实验室都在使用的毛细管气相色谱柱进行质量选择性检测的分析过程。尸检毒理学结果显示，血液中氯二氟甲烷和氯五氟乙烷的浓度分别为71毫克/升和0.30毫克/升。氯二氟甲烷在大脑、肝脏和肺部的浓度分别为（毫克/千克）2.8、4.4和1.6。氯五氟乙烷在大脑、肝脏和肺部的浓度分别为（毫克/千克）0.80、0.80和0.11。受害者血液中含有5.5毫克/升咖啡因。用于复苏尝试的利多卡因也存在于受害者血液中。在受害者血液中未检测到其他可碱提取的药物或挥发性醇类。死亡原因是吸入氯氟烃导致急性呼吸骤停。
