Volkow N D, Fowler J S, Wang G J, Dewey S L, Schlyer D, MacGregor R, Logan J, Alexoff D, Shea C, Hitzemann R
Medical and Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973.
J Nucl Med. 1993 Apr;34(4):609-13.
Carbon-11-raclopride has been successfully utilized with PET to assess changes in endogenous dopamine concentration after pharmacological intervention in the living baboon brain. For similar studies to be done in humans, measurements of 11C-raclopride with no intervention need to be reproducible. In order to test the reproducibility (test-retest) of 11C-raclopride binding in the human brain, we performed repeated studies on two different days. Studies were done in five normal controls with no pharmacological intervention. Time-activity (%dose/cc) curves for 11C-raclopride in the basal ganglia (BG) and cerebellum (CBL) were highly reproducible with an average difference in peak uptake for repeated studies in the same individual of 4%. The BG to CBL ratio for the average activity concentration between 30 and 60 min showed differences that ranged from -7% to 8% between the repeated studies. Graphical analysis to obtain the distribution volume revealed intrasubject values that ranged from -9% to 7% for the ratio of the distribution volume in BG to that in CBL. These studies demonstrate that in order to use 11C-raclopride to measure an individual's change in relative dopamine concentration secondary to pharmacological or behavioral intervention, a change in striatal 11C-raclopride binding in excess of 10% is required.
碳 -11 雷氯必利已成功用于正电子发射断层扫描（PET），以评估在活体狒狒大脑中进行药物干预后内源性多巴胺浓度的变化。为了在人类中进行类似研究，在无干预情况下对碳 -11 雷氯必利的测量结果需要具有可重复性。为了测试碳 -11 雷氯必利在人脑中结合的可重复性（重测），我们在两个不同的日子进行了重复研究。研究在五名未进行药物干预的正常对照者中进行。基底神经节（BG）和小脑（CBL）中碳 -11 雷氯必利的时间 - 活性（%剂量/立方厘米）曲线具有高度可重复性，同一受试者重复研究的峰值摄取平均差异为 4%。30 至 60 分钟之间平均活性浓度的 BG 与 CBL 比值在重复研究之间的差异范围为 -7%至 8%。通过图形分析获得分布容积，BG 与 CBL 中分布容积比值的受试者内值范围为 -9%至 7%。这些研究表明，为了使用碳 -11 雷氯必利测量个体因药物或行为干预导致的相对多巴胺浓度变化，纹状体中碳 -11 雷氯必利结合的变化需要超过 10%。
