Stabin M G
Radiation Internal Dose Information Center, Oak Ridge Institute for Science and Education, Tennessee 37831-0117.
J Nucl Med. 1993 Apr;34(4):695-6.
Thyroid cancer patients sometimes receive conventional external irradiation to the neck in addition to radioactive iodine therapy. In these situations, knowledge of the radiation dose already received by the spine in the neck area from the radioiodine administration can be an aid in treatment planning. This paper gives an estimate of the radiation dose to the upper spine from administration of 3700 MBq of 131I-sodium iodide. Monte Carlo codes used to estimate radiation dose from internal emitters usually give absorbed doses to the whole spine or marrow. One such code was modified to give a dose only to the upper spine region near the thyroid. Calculations assumed a thyroid uptake of 10% of administered activity and retention with a 35-hr effective half-time. Activity in the remainder of the body was assumed to clear with a 6-hr half-time to urine. Under these assumptions, the dose to this upper spine region was about 200 mGy.
甲状腺癌患者有时除接受放射性碘治疗外，还会接受颈部常规外照射。在这些情况下，了解颈部区域脊柱因放射性碘给药已经接受的辐射剂量有助于治疗计划的制定。本文给出了给予3700MBq 131I-碘化钠后上脊柱所受辐射剂量的估计值。用于估计体内发射体辐射剂量的蒙特卡罗代码通常给出整个脊柱或骨髓的吸收剂量。对其中一个这样的代码进行了修改，使其仅给出甲状腺附近上脊柱区域的剂量。计算假设甲状腺摄取给药活度的10%，并以35小时的有效半衰期潴留。假设身体其余部分的活度以6小时的半衰期清除至尿液中。在这些假设下，该上脊柱区域所受剂量约为200mGy。
