Stol M, Smetana K
Institute of Rheumatology, Prague, Czech Republic.
J Biomater Appl. 1993 Jan;7(3):224-32. doi: 10.1177/088532829300700302.
Linear and three-dimensional polymer composites were prepared on the basis of poly(2-hydroxyethyl methacrylate)--pHEMA--and collagen. Their biological properties were tested by in vitro as well as in vivo methods. The composite material (unlike pure pHEMA) supported myoblast adhesion as well as their fusion into multinuclear myotubes in vitro. The three-dimensional polymer composites stimulated a new bone formation after their intraosseal implantation in dogs and pigs. The biomaterial itself was degraded in the host organism, in contrast to stable pHEMA.
基于聚甲基丙烯酸2-羟乙酯（pHEMA）和胶原蛋白制备了线性和三维聚合物复合材料。通过体外和体内方法测试了它们的生物学特性。复合材料（与纯pHEMA不同）在体外支持成肌细胞黏附以及它们融合形成多核肌管。三维聚合物复合材料在犬和猪的骨内植入后刺激了新骨形成。与稳定的pHEMA相比，生物材料本身在宿主体内发生降解。
