Marcuard S P, Finley J L, MacDonald K G
Department of Medicine, East Carolina University, School of Medicine, Greenville, NC 27858-4354.
JPEN J Parenter Enteral Nutr. 1993 Mar-Apr;17(2):187-90. doi: 10.1177/0148607193017002187.
This is a first report of three patients with silicone feeding tubes (two with percutaneous endoscopic gastrostomies and one with a jejunostomy, all 20 French catheters) that have formed a thick yeast crust on the inner luminal surface causing tube occlusion in two cases. Candida species were isolated in all three tubes. The yeast crust could not be removed with a brush or with fungicidal drugs such as nystatin and amphotericin B. Histologic sections through these feeding tubes revealed yeast penetration through the silicone material, explaining the adherent nature of the crust. This complication may also explain the observed material deterioration with subsequent breakage.
这是关于三名使用硅胶饲管患者的首次报告（两名患者采用经皮内镜下胃造口术，一名患者采用空肠造口术，所有饲管均为20法式导管），这些饲管的管腔内表面形成了一层厚厚的酵母硬皮，导致两例患者出现导管堵塞。在所有三根饲管中均分离出念珠菌属。用刷子或制霉菌素、两性霉素B等杀真菌药物无法清除酵母硬皮。对这些饲管进行的组织学切片显示酵母穿透了硅胶材料，这解释了硬皮的附着特性。这种并发症也可能解释了观察到的材料变质及随后的破裂情况。
