Kaneko T, Katsu K, Fujimoto M, Yamauchi H, Algate D R, Beard D J, Jobling C M, Munt P L
Tsukuba Research, Laboratories, Eisai Co., Ltd.
Jpn J Antibiot. 1993 Jan;46(1):18-30.
The effects of cefclidin (CFCL), a novel antibacterial agent, on the central nervous system (CNS) were examined in a variety of animal models. The effects of cefazolin (CEZ) were also examined for comparative purposes. In the animal models used CFCL whilst having some effects at the doses examined, failed to show an overall consistent effect on the CNS. In contrast CEZ produced changes in the parameters measured which were generally consistent with a proconvulsant action.
在多种动物模型中研究了新型抗菌药物头孢利定（CFCL）对中枢神经系统（CNS）的影响。为作比较，还研究了头孢唑林（CEZ）的影响。在所使用的动物模型中，CFCL在所检测的剂量下虽有一些作用，但对中枢神经系统未能显示出总体一致的作用。相比之下，CEZ使所测参数发生变化，这些变化总体上与惊厥前作用一致。
