Becker J T, Wess J, Hunkin N M, Parkin A J
Department of Psychiatry, University of Pittsburgh, School of Medicine, PA.
Neuropsychologia. 1993 Feb;31(2):137-43. doi: 10.1016/0028-3932(93)90042-x.
Current theories of memory and memory dysfunction emphasize the importance of the use of contextual information in the storage and retrieval of specific episodes. Patients with lesions primarily in the diencephalon perform poorly on a measure of temporal recency, while those with temporal lobe amnesia are significantly better. The present study evaluated the ability of Probable AD patients to utilize information about temporal recency in the context of a recognition memory task. The performance of the AD patients was significantly impaired and resembled that of patients with Korsakoff's syndrome. The pattern of performance suggested that they were able to recognize which stimuli had been previously presented, but were unable to recall the correct temporal context. Further, there were no significant correlations between measures of temporal recency and those of frontal lobe function. These data suggest that AD patients, like other groups of patients with severe memory defects, are impaired at the use of context information in their attempts to remember recent events.
当前关于记忆和记忆功能障碍的理论强调了在存储和检索特定事件时使用情境信息的重要性。主要患有间脑病变的患者在时间新近性测试中表现不佳，而患有颞叶失忆症的患者表现则明显更好。本研究评估了可能患有阿尔茨海默病（AD）的患者在识别记忆任务情境中利用时间新近性信息的能力。AD患者的表现明显受损，类似于患有科萨科夫综合征的患者。表现模式表明，他们能够识别之前呈现过哪些刺激，但无法回忆起正确的时间背景。此外，时间新近性测量与额叶功能测量之间没有显著相关性。这些数据表明，AD患者与其他患有严重记忆缺陷的患者群体一样，在试图记住近期事件时，利用情境信息的能力受损。
