Taki J, Nakajima K, Bunko H, Shimizu M, Taniguchi M, Hisada K
Department of Nuclear Medicine, Kanazawa University School of Medicine, Japan.
Nucl Med Commun. 1993 Mar;14(3):181-8. doi: 10.1097/00006231-199303000-00006.
123I-labelled 15-(p-iodophenyl)-3-(R,S)-methylpentadecanoic acid (BMIPP) myocardial single photon emission computed tomography (SPECT) was performed in 17 patients with hypertrophic cardiomyopathy, and was compared with 201Tl exercise stress myocardial perfusion SPECT images. Fourteen patients showed asymmetrical hypertrophy, and three demonstrated apical hypertrophy. SPECT was performed 20 min and 3 h after injection of 111 MBq 123I-BMIPP at rest. Exercise stress 201Tl SPECT was performed at 10 min and 3 h after injection and was compared with BMIPP imaging. In 13 patients BMIPP accumulation in the hypertrophied area in the 20 min image was lower than that of 3 h 201Tl uptake. Interestingly, six patients demonstrated 201Tl redistribution in the region where the uncoupling of BMIPP uptake at 20 min and 201Tl accumulation at 3 h after exercise was observed. These findings suggest that impaired fatty acid metabolism or utilization in hypertrophic myocardium and ischaemia or impaired coronary flow reserve may be one of the causes of the abnormality of fatty acid accumulation.
对17例肥厚型心肌病患者进行了123I标记的15-（对碘苯基）-3-（R，S）-甲基十五烷酸（BMIPP）心肌单光子发射计算机断层扫描（SPECT），并与201Tl运动负荷心肌灌注SPECT图像进行比较。14例患者表现为不对称性肥厚，3例表现为心尖肥厚。静息状态下注射111 MBq 123I-BMIPP后20分钟和3小时进行SPECT检查。运动负荷201Tl SPECT在注射后10分钟和3小时进行，并与BMIPP成像进行比较。13例患者20分钟图像中肥厚区域的BMIPP摄取低于3小时201Tl摄取。有趣的是，6例患者在运动后20分钟BMIPP摄取与3小时201Tl摄取解偶联的区域出现了201Tl再分布。这些发现提示肥厚心肌中脂肪酸代谢或利用受损以及缺血或冠状动脉血流储备受损可能是脂肪酸摄取异常的原因之一。
