Okor R S
Department of Pharmaceutics, University of Benin, Nigeria.
Pharm Res. 1993 Feb;10(2):220-2. doi: 10.1023/a:1018930709603.
Aqueous dispersions of an acrylate-methacrylate, a water-insoluble copolymer, were prepared by a coacervation technique. Addition of sodium chloride (0.2 M) to the dispersion (10%, w/v) converted the system to a thixotropic gel which turns fluid on shaking and reverts to gel on standing. Phenol (0.03 M) inhibited the gelling effect of the electrolyte. Among the various phenolic compounds tested, phenol displayed the strongest and chlorocresol the weakest antigelling property. Sodium chloride reduced the electropotentials (index of particle-particle repulsiveness) of the polymer dispersions, while phenol increased the potentials. It is thought that the phenol solution acted as a dielectric which increased the interparticle repulsive potential, hence its antiflocculant effect.
通过凝聚技术制备了丙烯酸酯 - 甲基丙烯酸酯（一种水不溶性共聚物）的水分散体。向该分散体（10%，w/v）中加入氯化钠（0.2 M）可使体系转变为触变凝胶，该凝胶在振荡时变为流体，静置时又恢复为凝胶。苯酚（0.03 M）抑制了电解质的胶凝作用。在测试的各种酚类化合物中，苯酚表现出最强的抗胶凝性能，而氯甲酚表现出最弱的抗胶凝性能。氯化钠降低了聚合物分散体的电势（颗粒间排斥力的指标），而苯酚则提高了电势。据认为，苯酚溶液起到了电介质的作用，增加了颗粒间的排斥电势，因此具有抗絮凝作用。
